Methylenetetrahydrofolate reductase modulates methyl metabolism and lignin monomer methylation in maize
نویسندگان
چکیده
منابع مشابه
The maize brown midrib2 (bm2) gene encodes a methylenetetrahydrofolate reductase that contributes to lignin accumulation
The midribs of maize brown midrib (bm) mutants exhibit a reddish-brown color associated with reductions in lignin concentration and alterations in lignin composition. Here, we report the mapping, cloning, and functional and biochemical analyses of the bm2 gene. The bm2 gene was mapped to a small region of chromosome 1 that contains a putative methylenetetrahydrofolate reductase (MTHFR) gene, wh...
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Background: The most common polymorphisms identified in the Methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C lead to defective activity of this enzyme and increase the risk of venous and arterial thrombosis. There are limited investigations regarding the effects of thrombogenic polymorphisms on the clinical phenotypes of rare hereditary hemorrhagic disorders like Glanzmann's t...
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The aim of this study was to investigate the role of methylenetetrahydrofolate reductase (MTHFR) polymorphisms and MTHFR methylation pattern in cervical lesions development among women from Romania, a country with high prevalence of human papillomavirus (HPV) cervical infections. To achieve this goal, blood samples and cervical cytology specimens (n = 77)/tumour tissue specimens (n = 23) were i...
متن کاملThe association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer.
BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in folate metabolism, which is an important pathway of the methyl donor for DNA methylation. The MTHFR gene has genetic variants (C667T and A1298C), which cause reduced enzyme activity. Impaired folate metabolism by these genetic variants of MTHFR could change the methylation pattern of DNA including promoter hypermeth...
متن کاملFolate, vitamin B12, homocysteine and methylenetetrahydrofolate reductase (MTHFR) are involved in one-carbon transfer (methyl-
reductase (MTHFR) are involved in one-carbon transfer (methylation) reactions necessary for the production of monoamine neurotransmitters, phospholipids and nucleotides. Folate and vitamin B12 deficiency, hyperhomocysteinaemia and the T677 allele of the MTHFR gene, which cause impaired methylation reactions in the central nervous system, have been associated with depressive disorders. However n...
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ژورنال
عنوان ژورنال: Journal of Experimental Botany
سال: 2018
ISSN: 0022-0957,1460-2431
DOI: 10.1093/jxb/ery208